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Below is a breakdown of the highest-paid NP specialties, each requiring a graduate program in their chosen field before taking their certification exam—often with the help of a nurse practitioner review course.
1. Aesthetic Nurse Practitioner – $142,326
As of March 2025, according to Salary.com, Aesthetic Nurse Practitioners earns the highest salary of all nurse practitioner specialties, with an average annual salary of $142,326. ANPs specialize in cosmetic treatments such as Botox, dermal fillers, and laser procedures. Their earnings are often boosted by private practice and high client demand.
2. Neonatal Nurse Practitioner – $141,552
Neonatal NPs provide critical care to premature and high-risk newborns in neonatal intensive care units (NICUs), ensuring their survival and development.
3. Emergency Nurse Practitioner – $136,734
Emergency NPs work in fast-paced emergency departments, diagnosing and treating acute conditions, trauma cases, and critical illnesses.
4. Psychiatric Mental Health Nurse Practitioner – $131,703
PMHNPs assess, diagnose, and treat mental health disorders, providing therapy and medication management for patients with psychiatric conditions.
5. General Surgery Nurse Practitioner – $127,300
General Surgery NPs work alongside surgeons, assisting in operations, preoperative care, and postoperative patient management.
6. Family Nurse Practitioner – $127,170
FNPs offer primary care services to patients across all age groups, managing chronic illnesses, preventive care, and health education.
7. Interventional Radiology Nurse Practitioner – $126,477
These NPs assist in minimally invasive image-guided procedures such as biopsies, catheter placements, and angioplasty.
8. Cardiovascular Nurse Practitioner – $125,870
Cardiovascular NPs specialize in heart-related conditions, working with cardiologists to manage hypertension, heart disease, and post-surgical recovery.
9. Acute Care Nurse Practitioner – $125,048
Acute Care NPs provide treatment for critically ill patients in hospital settings, often managing conditions that require rapid intervention.
10. Women’s Health Nurse Practitioner – $116,660
WHNPs focus on reproductive health, prenatal care, menopause management, and gynecological conditions in women.
11. Adult-Gerontology Nurse Practitioner – $109,512
AGNPs specialize in caring for older adults, focusing on chronic disease management, mobility issues, and overall geriatric health.
Also, check out our article to find out what’s the easiest nurse practitioner specialty to get into and the least stressful nurse practitioner jobs.