Bupropion (Wellbutrin) Mnemonic

Published by Latrina Walden

  • February 21, 2025
  • 01:01

Latrina Walden

Founder & CEO of LWES | MSN, MHA, FNP-C, FNP-BC, PMHNP

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Meet The Author

Latrina Walden

Latrina is the Founder & CEO of Latrina Walden Exam Solutions (LWES). Her background is in creating a NP Academy that supports and educates current and future nurses through an Academy.
Follow her on Linkedin for more tips & advice in the nursing world.

Table of Contents

    Key Points

    • Bupropion (Wellbutrin) is an atypical antidepressant primarily used to treat depression and aid in smoking cessation.
    • Wellbutrin works by inhibiting the reuptake of dopamine and norepinephrine, enhancing the signaling of these neurotransmitters in the brain.
    • Bupropion is notable for its ability to promote weight loss and its lack of sexual side effects, making it distinct from other antidepressants.
    • It is contraindicated in patients with eating disorders such as bulimia or anorexia nervosa due to an increased risk of seizures.
    • Side effects of Bupropion include tachycardia, insomnia, and headaches.
    • Patients should avoid alcohol and not crush or chew the pills, as both can heighten the risk of seizures.

    Mechanism of Action

    • Bupropion inhibits the reuptake of norepinephrine and dopamine, increasing their levels in the brain to improve mood and reduce cravings.
    • It does not affect serotonin, making it different from most antidepressants like SSRIs and SNRIs.
    • Bupropion’s lack of impact on serotonin helps avoid side effects like sexual dysfunction, often seen with other antidepressants.
    • Its stimulant-like effects can also promote weight loss, though it may cause insomnia or increased heart rate in some patients.

    Indications

    • Bupropion is used to treat Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), and Seasonal Affective Disorder (SAD).
    • It also aids in smoking cessation, reducing withdrawal symptoms by mimicking nicotine’s effects on the brain.
    • Typically prescribed as a 2nd or 3rd line treatment for depression after SSRIs, and can be used as adjunctive therapy.
    • Classified as an atypical antidepressant, it offers an alternative treatment option, especially for patients who don’t respond well to SSRIs.

    Side Effects

    • Seizures are the primary side effect of bupropion.
      • It lowers the seizure threshold, and the risk increases with higher doses.
      • Contraindicated in patients with a history of seizure disorders, bulimia, or anorexia nervosa
      • Crushing or chewing the pills increases absorption and raises the seizure risk.
      • Patients should limit alcohol intake, as it can further lower the seizure threshold.
    • Does not cause sexual side effects, unlike SSRIs, which often cause sexual dysfunction.
    • Promotes weight loss, in contrast to SSRIs and mirtazapine, which can cause weight gain.
    • Side effects like tachycardia, insomnia, and headaches may occur.
    • Increased risk of suicidal behavior early in treatment, particularly in adolescents and young adults.

    Bonus Mnemonic: “BUPROPION”

    • B - Bulimia and anorexia nervosa contraindicated (due to seizure risk)
    • U - Under no circumstances should the dose be doubled if missed
    • P - Pill must be taken at the same time every day
    • R - Risk of seizures increases with higher doses
    • O - Overuse of alcohol lowers the seizure threshold further
    • P - Pills must not be crushed or chewed (raises absorption and risk of seizures)
    • I - Increased risk of seizures in patients with a history of seizure disorders
    • O - Out of control seizures are the primary side effect
    • N - No sexual side effects

    Want to learn more mnemonics for buspirone or atypical antidepressants mnemonics.

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